Neither receiver Mario Manningham nor running back LaMichael James made the trip to Denver, according to the 49ers. Manningham sent out a one-word tweet on Saturday: "hurting," in reference to his grandfather, who passed away last week.
"Lost for words," Manningham wrote Friday. "I just lost a man that knows me better than anyone can imagine ðŸ™ have mercy on me!!! Rip Big Daddy ðŸ‘‘"
Meanwhile, James suffered an ankle injury late in last week's game against Houston. However, he returned to practice Tuesday and seemed to be operating without a limp. Running back Brandon Jacobs (knee) also did not make the trip, meaning that backups Rock Cartwright and Anthony Dixon promise to get plenty of action today in Denver.
The other players who did not make the trip are receiver Joe Hastings, outside linebacker Kourtnei Brown (hamstring), outside linebacker Darius Fleming (knee), running back Jewel Hampton and cornerback Chris Culliver. Culliver said he is dealing with a right knee injury suffered in last week's game. Either Tramaine Brock or Perrish Cox will step in as the No. 3 cornerback.
Both Aldon Smith and NaVorro Bowman went through warm-ups as the 49ers prepare to take on the Broncos in Denver. Smith (hip) returned to practice this week but was not a full go throughout the week. Bowman, meanwhile, has an apparent knee injury and did not practice on Wednesday or Thursday.
It's not known if either will play. If Smith sits out this game, Parys Haralson likely would start at right outside linebacker. Bowman's absence would mean that Larry Grant starts next to Patrick Willis at inside linebacker. Also, rookie outside linebacker Cam Johnson (knee) did not warm up with the 49ers and is unlikely to play.
Randy Moss will start at wide receiver for the 49ers, according to the pre-game report. Presumably, Michael Crabtree will start at the other receiver spot.
-- Matt Barrows