Brandon Jacobs, who said all last week that he was past an August knee injury and was ready to play, is inactive today against the Bills. Another running back, LaMichael James, also is inactive for the fifth time this season.
In fact, all of the 49ers draft picks are inactive for the second straight game. The only rookie in uniform will be tight end Garrett Celek. The other 49ers inactives: quarterback Scott Tolzien, nose tackle Ian Williams, safety Trenton Robinson, guard Joe Looney and wide receiver A.J. Jenkins.
Jacobs practiced throughout the week, and the expectation was that today's game would serve as a warm-up for next week's game against his former team, the Giants. The 49ers, however, might have had trouble finding room in the lineup for Jacobs, who doesn't play special teams. The 49ers listed Jacobs as questionable for today's game. Carlos Rogers and Isaac Sopoaga also were questionable; both will start.
San Francisco already has three tailbacks active for today's game. Frank Gore and Kendall Hunter are the team's leading rushers; Anthony Dixon is a core player of special teams.
The Bills' inactives: quarterback Tarvaris Jackson, running back Johnny White, strong safety Delano Howell, linebacker Kirk Morrison, guard Kraig Urbik, tackle Cordy Glenn and defensive tackle Spencer Johnson.
Chris Hairston will start at left tackle for Glenn; Chad Rhinehart will start at right guard for Urbik.
-- Matt Barrows