Running back Brandon Jacobs is among the 49ers who are inactive for today's game.
Jacobs appeared decidedly frustrated during a Wednesday interview with USA Today, saying that he had been healthy enough to play against the Jets and the Bills in recent weeks. A day later - and perhaps after a talk with Jim Harbaugh - the big running back was more conciliatory.
He said he had a rare chance to be "100 percent healthy" and noted that the 49ers expected to be playing big games in December, January and perhaps February. "Right now, could I go out and play?" Jacobs asked Thursday. "Yes. But would it be smart? No."
Jacobs injured his knee Aug. 18. He has been a full participant in practice for the last two weeks.
For the third straight week, undrafted tight end Garrett Celek is the only 49ers rookie in uniform today. The other 49ers inactives are: quarterback Scott Tolzien, receiver A.J. Jenkins, running back LaMichael James, safety Trenton Robinson, guard Joe Looney and nose tackle Ian Williams.
For the Giants, receiver Hakeem Nicks (foot, knee) is active for the first time since Week 2. Markus Kuhn will start at defensive tackle for Rocky Bernard (Alex Smith is happy about that) while Nicks will start for Dominik Hixon.
For the Giants, WR Jerrel Jernigan, S Kenny Phillips, RB Andre.Brown, DE Adewale Ojomo, T James Brewer, TE Adrien Robinson and Bernard are inactive.
Like Demarcus Dobbs earlier this year, defensive end Will Tukuafu has switched numbers. Tukuafu is now wearing No. 48, which means he won't have to check in with officials when he enters the game as a fullback. he's also now listed as a fullback/defensive end. Tukuafu formerly wore No. 92.
-- Matt Barrows