Both Joe Staley (concussion) and Brandon Jacobs (knee) are active for today's game against the Seattle Seahawks. Receiver Mario Manningham, however, is dealing with a shoulder injury and will not play.
Manningham has started the last three games at receiver for the 49ers. The team has not announced who will take his place -- and it likely will depend on their opening formation -- but a good bet is that Randy Moss will start his second game this year.
The other 49ers inactives are Scott Tolzien, A.J. Jenkins, LaMichael James, Joe Looney, Trenton Robinson and Ian Williams.
That Jacobs is active for the first time this season may signal a re-dedication to the running game after the 49ers got away from the ground attack after Sunday's loss to the Giants. Staley, meanwhile, suffered a concusion in the third quarter Sunday when he went helmet to helmet with strong safety Stevie Brown following an interception. Staley also was concused on Dec. 11 last season. He said that injury was more severe than the current one.
For the Seahawks, the inactives are: WR Charly Martin, SS Winston Guy, CB Danny Gorrer, CB Byron Maxwell, G J.R. Sweezy, G John Moffit and DT Jaye Howard
-- Matt Barrows