First-round draft pick A.J. Jenkins is active for only the second time this season. The player the 49ers drafted in the second round, running back LaMichael James, is not active. The 49ers lost running back Kendall Hunter for the season last week, and there was a thought that James could see his first snaps of the season.
The backup duties instead will be divided among Brandon Jacobs, who has one carry for one yard, and Anthony Dixon, who is one of the team's core special teams players. Rookie running back Jewel Hampton also in inactive today.
James' lack of activity likely is due to special teams. Cornerback Perrish Cox will serve as the backup return man behind Ted Ginn. James does not play on the coverage units as does, say, Dixon.
Ginn likely will step into Kyle Williams' role at receiver, but it's possible Jenkins could see his first action of the year. Jenkins was in uniform in Week 1 when Ginn (ankle/knee) was inactive, but he did not play a snap.
The other 49ers inactives are: quarterback Scott Tolzien, safety Trenton Robinson, guard Joe Looney, tight end Demarcus Dobbs and and nose tackle Ian Williams.
Dobbs was arrested Friday morning after a solo car crash. He was arrested for suspicion of DUI and marijuana possession. Also active is safety Darcel McBath, who suffered a concussion last week in New Orleans.
For the Rams, Danny Amendola (foot) will not play. Amendola had 102 yards in the teams' first meeting this year. Chris Given will start in Amendola's place. Givens, along with fellow rookie Janoris Jenkins, was suspended for the teams' first meeting for breaking curfew.
The other Rams inactives: QB Austin Davis, LB Mario Haggan, T Joe Barksdale, RB Terrance Ganaway, OL Chris Williams and DT Matt Conrath.
-- Matt Barrows