The 49ers, who went into Sunday's game in Seattle with only one player, LaMichael James, on their injury report, emerged from it with 10 injured players, including quarterback Colin Kaepernick and the team's entire starting defensive line.
Kaepernick is listed with a foot injury but practiced in full Wednesday. So did left guard Mike Iupati, who has a shoulder injury. Iupati had surgery on his shoulder this offseason and didn't take part in the team's May and June OTA sessions.
Defensive ends Ray McDonald (ankle, ankle) and Justin Smith (shoulder) did not practice at all. McDonald's injury is not a typo. He has injuries to both ankles, though it was an apparent right ankle sprain that knocked him out of Sunday's game. Starting nose tackle Ian Williams was lost for the season when he suffered a broken ankle in the first quarter.
The others who did not practice were tight end Vernon Davis, who suffered a hamstring strain in the fourth quarter, and James, who still is dealing with a knee injury suffered in the preseason finale.
Starting defensive players NaVorro Bowman (wrist), Eric Reid (concussion) and Aldon Smith (back) were limited in practice. Reid practiced in a blue, non-contact uniform. He has not shown any symptoms since his concussion against the Seahawks but still must pass the league's post-concussion protocol before being cleared to play Sunday against the Colts.
Aldon Smith, meanwhile, briefly left Sunday's game and was replaced by rookie Corey Lemonier. Still, Smith finished the game and had two sacks. He has three and a half on the season, tying him for third place.
-- Matt Barrows