Vernon Davis said he's waiting for team doctors to give him the go-ahead to play Sunday, which would be the first game he's ever played against his younger brother, Colts cornerback Vontae Davis.
Vernon Davis, who suffered a left hamstring strain late in Sunday's loss to Seattle, was the only 49er who did not practice Friday. He is listed as questionable on the team's injury report.
The 49ers tight end said he was able to run on a side field while the rest of the team practiced Friday. "I'm feeling pretty good, sore, bruised up, but that comes with the business, comes with the game," he said. " Definitely my focus is on this game. .. We shall see when Sunday comes."
Davis said he was surprised the injury occurred since he spends so much time before and after practice stretching his hamstrings, groin and calves. "That's all I do," he said. "When you guys don't see me, I'm in here stretching."
If Davis can't play, backups Vance McDonald and Garrett Celek would step in. It also might lead to Chris Harper's debut. Acquired just before the season began, Harper is listed as a receiver but is studying how to play the tight-end role Delanie Walker had the last two seasons. Harper has been inactive the first two games.
Vontae Davis, meanwhile, was a first-round pick by the Dolphins in 2009. He was traded to Indianapolis last year.
Defensive end Ray McDonald practiced Friday for the first time this week and said he expects to play against the Colts. McDonald, Davis, running back LaMichael James (knee) and safety Eric Reid (concussion) are listed as questionable. Reid also is on track to play, but must pass one final step in the league's post-concussion protocol.
Linebacker NaVorro Bowman (wrist), guard Mike Iupati (shoulder), quarterback Colin Kaepernick (foot), linebacker Aldon Smith (back) and Justin Smith (shoulder) are listed as probable.