The 49ers hit the ground running against the Titans - including quarterback Colin Kaepernick, who scored his first rushing touchdown of the season on a 20-yard score in the second quarter and who leads all rushers with five carries for 50 yards.
San Francisco's opening drive went 12 plays, with nine of them runs. That possession was capped by a 44-yard field goal from Phil Dawson. The second-quarter touchdown drive went eight plays and was marked by two excellent catches by receiver Anquan Boldin, one of them a one-handed snag as he was going out of bounds.
It also included a timely roughing-the-passer call against the Titans that wiped out an interception by safety Bernard Pollard. Kaepernick was trying to hit Vernon Davis, last week's offensive hero, along the sideline, but Pollard had positioned himself deep and was ready for the throw. The Titans nearly came away with another deep pass intended for Davis earlier in the second quarter.
Kaepernick's touchdown came on third and seven. He has run out of the read option four times so far, which is more than in any other game after Week 1. He received key blocks by fullback Bruce Miller, tight end Vance McDonald and, at the very end, Frank Gore, on the run.
The 49ers also received another big defensive play from Tramaine Brock, who has created distance between himself and Nnamdi Asomugha in the competition to be the No. 3 cornerback. Brock had excellent position on an underthrown pass from Jake Locker down the right sideline.
From there, Kaepernick led a six-play drive that included another big run from him and a pass to McDonald to the one-yard line. From there, San Francisco sent in its effective heavy-jumbo package - Adam Snyder and Daniel Kilgore added to the offensive line - and Gore tumbled in for a short touchdown to make the score 17-0.
-- Matt Barrows