The two will be sworn in as members of the U.S. House of Representatives on Thursday. A spokesman for Senate President Pro Tem Darrell Steinberg confirmed that both members have submitted their letters of resignation, which take effect later today.
Negrete McLeod, of Chino, ousted Democratic Rep. Joe Baca in the Inland Empire's 35th Congressional District, while Vargas won election in San Diego's open 51st Congressional District.
Special primary elections to fill the vacant Senate seats will be held in the coming months, on a date set by Gov. Jerry Brown.
Candidates for Negrete McLeod's 32nd Senate District seat include Assemblywoman Norma Torres, D-Pomona, and San Bernardino County Auditor-Controller Larry Walker.
Democratic Assemblyman Ben Hueso of San Diego, meanwhile, has announced his candidacy to succeed Vargas in the 40th Senate District.
PHOTO CREDITS: Left, then Assemblyman Juan Vargas, D-San Diego. John Decker / Sacramento Bee file, 2003. Right, Sen. Gloria Negrete McLeod, D-Chino, speaks at the Senate session in Sacramento, on June 14, 2012. AP Photo / Rich Pedroncelli.