Fatima Scott, 16, who had been staying with her family at a motel on Point East Drive in Rancho Cordova, is considered at-risk because she is without needed medication.
Scott was last seen riding light rail in downtown Sacramento at about 7:30 p.m. Thursday.
She is described as black, 5 feet 6 inches tall and about 135 pounds. She was wearing a pink shirt and blue jeans. Her head is shaved but she does wear a blond and black wig.
Anyone who has seen Scott is asked to call police at (916) 874-5115.
PHOTO CAPTION: Fatima Scott